Acanthosis nigricans
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References
Acanthosis nigricans je kožný prejav základného ochorenia. Často sa objavuje v kožných záhyboch, ako je krk, podpazušie a slabiny, a vyzerá ako zamatovo tmavé škvrny s nejasnými okrajmi. Tento stav je zvyčajne spojený s cukrovkou a inzulínovou rezistenciou, ale v zriedkavých prípadoch môže poukazovať na rakovinu vo vnútri tela. Môže sa objaviť aj v dôsledku hormonálnych problémov alebo užívania špecifických liekov, ako sú steroidy a antikoncepčné pilulky.
Acanthosis nigricans is a cutaneous manifestation of an underlying condition. It usually develops in skin folds, such as the back of the neck, axilla, and groin, where it presents as velvety hyper-pigmented patches with poorly defined borders. Acanthosis nigricans is most commonly associated with diabetes and insulin resistance, but rarely it can be a sign of internal malignancy. It can also occur with hormone disorders or with the use of certain medications like systemic glucocorticoids and oral contraceptives.
Acanthosis nigricans is a cutaneous manifestation of an underlying condition. It usually develops in skin folds, such as the back of the neck, axilla, and groin, where it presents as velvety hyper-pigmented patches with poorly defined borders. Acanthosis nigricans is most commonly associated with diabetes and insulin resistance, but rarely it can be a sign of internal malignancy. It can also occur with hormone disorders or with the use of certain medications like systemic glucocorticoids and oral contraceptives.
Acanthosis nigricans (AN) je bežný stav kože spojený s rôznymi zdravotnými problémami, ako je inzulínová rezistencia, cukrovka, obezita, niektoré druhy rakoviny, hormonálne problémy a reakcie na lieky. Liečba AN sa zameriava na riešenie základných zdravotných problémov. Spočiatku lekári kontrolujú príznaky syndrómu inzulínovej rezistencie, ktorý zahŕňa obezitu, vysoký cholesterol, vysoký krvný tlak a cukrovku 2. Typu. Lekári často predpisujú topical retinoids ako prvú voľbu liečby, ktorá môže pomôcť so zhrubnutím kože. Avšak nemusia úplne riešiť stmavnutie pokožky. Iné možnosti liečby ako salicylic acid, podophyllin, urea, and calcipotriol tiež vyžadujú častú aplikáciu.
Acanthosis nigricans (AN) is a common dermatologic manifestation of systemic disease that is associated with insulin resistance, diabetes mellitus, obesity, internal malignancy, endocrine disorders, and drug reactions. Treatment of AN primarily focuses on resolution of the underlying disease processes causing the velvety, hyperpigmented, hyperkeratotic plaques found on the skin. Initial considerations for the AN workup include evaluating patients for insulin resistance syndrome characterized by obesity, dyslipidemia, hypertension, and diabetes mellitus type II. For cosmetic treatment, topical retinoids are considered the first-line therapy for insulin-resistant AN by modifying keratinization rate. However, topical tretinoin requires application for long durations and improves hyperkeratosis, but not hyperpigmentation. Topical salicylic acid, podophyllin, urea, and calcipotriol also require frequent application, while TCA peels may provide a faster and less time-intense burden.
Acanthosis nigricans (AN) is a common dermatologic manifestation of systemic disease that is associated with insulin resistance, diabetes mellitus, obesity, internal malignancy, endocrine disorders, and drug reactions. Treatment of AN primarily focuses on resolution of the underlying disease processes causing the velvety, hyperpigmented, hyperkeratotic plaques found on the skin. Initial considerations for the AN workup include evaluating patients for insulin resistance syndrome characterized by obesity, dyslipidemia, hypertension, and diabetes mellitus type II. For cosmetic treatment, topical retinoids are considered the first-line therapy for insulin-resistant AN by modifying keratinization rate. However, topical tretinoin requires application for long durations and improves hyperkeratosis, but not hyperpigmentation. Topical salicylic acid, podophyllin, urea, and calcipotriol also require frequent application, while TCA peels may provide a faster and less time-intense burden.
○ Príčiny
Typicky sa vyskytuje u jedincov mladších ako 40 rokov, môže byť geneticky zdedená a je spojená s obezitou alebo endokrinopatiami, ako je hypotyreóza, akromegália, ochorenie polycystických ovárií, inzulín-rezistentný diabetes alebo Cushingova choroba.
○ Liečba - Voľne predajné lieky
#40% urea cream